Vitamin D.sub.3 metabolite derivatives
AssigneeHoffmann-La Roche Inc.
InventorsEnrico G. Baggiolini, Milan R. Uskokovic
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Abstract
This disclosure relates to 3-hemisuccinate or 3-hemiglutarate derivatives of the biologically active metabolites of Vitamin D.sub.3 which possess Vitamin D activities and uses. The subject compounds also are useful as haptens which can be used to prepare immunogens which in turn elicit antibodies selective to said respective Vitamin D.sub.3 metabolites.
Claims6
A compound of the formula ##STR6## where R.sub.1, R.sub.24, R.sub.25 and R.sub.26 each independently are hydrogen hydroxy, or fluorine provided that at least one of R.sub.1 -R.sub.24, R.sub.25 and R.sub.26 is hydroxy or fluorine, any two of R.sub.24, R.sub.25 and R.sub.26 taken together are hydroxys protected as the acetonide, and n is an integer selected from 2 or 3.
A compound of the formula ##STR7## where R.sub.1, R.sub.24, R.sub.25 and R.sub.26 each independently are hydrogen hydroxy, or fluorine provided that at least one of R.sub.1 -R.sub.24, R.sub.25 and R.sub.26 is hydroxy or fluorine, any two of R.sub.24, R.sub.25 and R.sub.26 taken together are hydroxys protected as the acetonide, and n is an integer selected from 2 or 3.
The compound of clam 3 which is 1.alpha.,25-dihydroxyprecholecalciferol-3-(2',2',2'-trichloroethyl)succina te.
A compound of the formula ##STR8## where R.sub.1, R.sub.24, R.sub.25 and R.sub.26 each independently are hydrogen hydroxy or fluorine, provided that at least one of R.sub.1, R.sub.24, R.sub.25 and R.sub.26 is hydroxy or fluorine, any two of R.sub.24, R.sub.25 and R.sub.26 taken together are hydroxys protected as the acetonide, and n is an integer selected from 2 or 3.
Dependencies are inferred from the claim text.