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US 4,225,472 AGranted
Truncated somatostatin analogs
AssigneeAmerican Home Products Corporation
InventorDimitrios Sarantakis
Life of this patent
Estimating the term…
Abstract
Polypeptides of the formula: ##STR1## in which X.sub.1 is hydrogen, des-amino, Ala-Gly- or Ala-D-Ala; X.sub.2 is Trp, Leu, Met or p-Cl-Phe; and X.sub.3 is D-Trp or 5- or 6-fluoro-D-Trp; the linear precursor intermediates thereof or pharmaceutically acceptable salts thereof are selective inhibitors of growth hormone and glucagon release without materially altering blood serum levels of insulin.
Claims5
A compound of the formula ##STR5## in which X.sub.1 is hydrogen, des-amino- Ala-Gly- or Ala-D-Ala-;
- X.sub.3 is D-Trp or 5- or 6- fluoro-D-Trp;
- and the A groups are hydrogen or a direct bond between the two sulfur atoms;
- or a pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.