Back to results
US 4,224,448 AGranted
2'-(5'-Nitrofuryl) substituted quinolines
OwnerRaphael R. G. Haber, Eva Schoenbergerinventors
Life of this patent
Estimating the term…
Abstract
2- and 4- (5'nitrofuryl) quinoline derivatives which may be variously substituted on the quinoline nucleus have been found to possess excellent antibacterial and antifungal activity. Procedures for their manufacture are disclosed.
Claims26
A nitrofuryl quinoline of the formula:
- ##STR14## in which R is hydrogen, 5-nitrofuryl, lower alkyl, halo-substituted lower alkyl, lower alkanoyloxy-lower alkyl, lower alkoxy or hydroxy-lower alkyl;
- R' is hydrogen, 5-nitrofuryl or lower alkyl;
- X is hydrogen, halogen, hydroxy, lower alkoxy, or lower alkyl;
- Y is hydrogen or lower alkyl;
- Z is hydrogen, nitro, lower alkyl or lower alkoxy;
- A is hydrogen or lower alkyl;
- B is hydrogen, lower alkyl, nitro or lower alkoxy;
- or X and Y taken together complete a benzene nucleus;
- at least one of substituents R and R' being a 2-(5-nitrofuryl) group;
- wherein A, B, X, Y and Z are non-tertiary lower alkyl when adjacent to groups other than hydrogen;
- and when X is hydroxy, R, R', B and Z are not lower alkoxy;
- and their nitrogen oxides and non-toxic acid addition salts.
9 more elements
Dependencies are inferred from the claim text.