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US 4,221,869 AGranted
Enzymatic synthesis of L-carnitine
AssigneeInstitut Francais du Petrole
InventorsJean-Paul Vandecasteele, Jeannine Lemal
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Abstract
L-carnitine is obtained by reacting 3-dehydrocarnitine or one of its salts, in aqueous medium, simultaneously with: (a) carnitine dehydrogenase, (b) a coenzyme utilized by carnitine dehydrogenase for reducing dehydrocarnitine, preferably nicotinamide adenine dinucleotide, and (c) a reducing agent for the coenzyme, the coenzyme (b) and carnitine dehydrogenase being preferably used in catalytic amount.
Claims23
A process for producing L-carnitine, which comprises reacting 3-dehydrocarnitine or one of its salts, in aqueous medium, simultaneously with:
- (a) carnitine dehydrogenase,
- (b) a coenzyme which may be utilized by carnitine dehydrogenase for reducing dehydrocarnitine, and
- (c) a reducing agent for the coenzyme.
Dependencies are inferred from the claim text.