US 4,219,426 AGranted

Dialysis device

AssigneeOrganon Teknika Corporation

InventorsHendrikus J. Spekle, Johannes P. Brants

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Abstract

The invention relates to a separating device, more particularly for hemodialysis, comprising a housing accommodating at least one bundle of a large number of tubular, selectively permeable membranes connected in parallel whose transverse dimensions are very small relative to their longitudinal dimensions. The ends of the membranes rest on supporting members in the housing. The membranes may be the walls of hollow fibers which divide the internal part of the separating device into a first medium space provided by the inside of the membranes and a second medium space inside the housing but outside the membranes. The medium spaces are each provided with an inlet and an outlet for respectively the supply and the discharge of a first and a second medium, which media can enter into exchange through the walls of the membranes.

Claims16

Dependent claims

A dialysis device comprising

an elongated tubular member,
a ring with a diameter larger than the diameter of the tubular member and disposed in concentric overlapping arrangement about each end portion of the tubular member secured thereto in radially outwardly spaced relationship to form an annular space therebetween, each end portion of said tubular member having circumferentially spaced crenels,
a bundle of hollow regenerated cellulose fibers disposed in the tubular member with ends disposed adjacent the ends of the tubular member,
longitudinally-spaced annular soft rubber-like rings substantially impassable to a liquid passing through said device and disposed in the tubular member about the bundle,
a solid elastomeric composition filling voids about the ends of the fibers and sealing the ends of the tubular member against longitudinal liquid flow therefrom, said composition also sealing the open ends of said annular space but not sealing all of the spaces between crenels whereby liquid can flow from an annular space into the space about the fibers in the tubular member at one end of the tubular member and out of the space in the tubular member into the annular space at the opposite end of the tubular member,
means for introducing dialysis fluid into one annular space,
means for removing dialysis fluid from the other annular space to create flow of dialysis fluid in the tubular member about the fibers,
convex disks having an annular prong near their peripheral edges impressed in said elastomeric composition radially outwardly from the fibers sealing a space between the disk and the end of the fiber bundle, said disks being end closure members for the tubular member,
means for the flow of blood into one of the last said spaces and into the fibers, and
means for the flow of blood from the second of the last said spaces.

7 more elements

A separating device, adapted for hemodialysis, comprising

an elongated tubular housing,
at least one bundle of a large number of parallel, hollow, selectively permeable fibers accommodated in said housing, whose ends are disposed adjacent the ends of the housing,
supporting members embedding the ends of said hollow fibers, and formed of a solid synthetic polymeric casting composition filling voids about the ends of the fibers and sealing the ends of said tubular housing,
a blood space provided by the inside of said hollow fibers,
a dialysis space located inside said housing but outside said hollow fibers,
inlets provided with said blood space and said dialysis space for the supply of blood and dialysis liquid thereto, respectively, which media can enter into exchange through the walls of said hollow fibers,
outlets provided with said blood space and said dialysis space for the discharge of blood and dialysis liquid therefrom, respectively,
at least one ring-like constriction substantially impassable to said dialysis liquid and placed in a manner wherein the exterior surface of said constriction contacts the inner wall of the dialysis space of said housing, at least part of said constriction being elastic, said elastic part bearing against said bundle and substantially extending in a circumferential direction about said bundle, but only partly along the length of the bundle(s), and
convex disks having an annular prong near their peripheral edges impressed in said polymeric casting composition radially outwardly from the fibers sealing a space between a disk and the end of the fiber bundle, said disks being end closure members for the tubular housing.

6 more elements

Dependencies are inferred from the claim text.