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US 4,216,160 AGranted
Substituted mercapto acid amides and their use
AssigneeMerck & Co., Inc.
InventorsConrad P. Dorn, Howard Jones
Life of this patent
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Abstract
Substituted mercapto acid amides are prepared, and are useful as immunoregulants for correcting an imbalance of immune homeostasis, particularly as immunostimulants in the treatment of autoimmune and immune deficient diseases and disorders.
Claims7
A compound of structural formula:
- ##STR60## n is 1 to 4;
- R is (a) hydrogen;
- ##STR61## where R.sub.5 is
- (1) C.sub.1-4 alkyl;
- (2) C.sub.1-4 alkoxy C.sub.1-4 alkyl;
- (3) C.sub.3-6 cycloalkyl;
- (4) phenyl;
- (5) phenyl C.sub.1-4 alkyl;
- or
- (6) C.sub.1-4 alkoxycarbonyl C.sub.1-4 alkyl;
- ##STR62## R.sub.1 and R.sub.2 may be the same or different and are independently selected from
- (a) hydrogen;
- and
- (b) C.sub.1-4 alkyl;
- and
- R.sub.3 and R.sub.4 may be the same or different and are independently selected from
- (a) hydrogen;
- (b) C.sub.1-4 alkyl;
- and ##STR63## where R.sub.5 is
- (1) C.sub.1-4 alkyl;
- (2) C.sub.1-4 alkoxy C.sub.1-4 alkyl;
- (3) C.sub.3-6 cycloalkyl;
- (4) phenyl;
- (5) phenyl C.sub.1-4 alkyl;
- or
- (6) C.sub.1-4 alkoxycarbonyl C.sub.1-4 alkyl;
- provided that, with regard to all of the above substituents, at least one carbonyl-containing group is selected.
24 more elements
Dependencies are inferred from the claim text.