Back to results
US 4,215,215 AGranted
9-Phenyl-nonate traene compounds
AssigneeHoffmann-La Roche Inc.
InventorsWerner Bollag, Rudolf Ruegg, Gottlieb Ryser
Life of this patent
Estimating the term…
Abstract
Novel 9-phenyl 5,6-dimethyl-nona-2,4,6,8-tetraenoic acid, tetraenal or tetraenol derivatives useful as anti-tumor agents.
Claims30
A compound of the formula:
- ##STR17## wherein R.sub.1 and R.sub.2 are lower alkyl;
- R.sub.3 is hydrogen, lower alkyl, lower alkoxy, lower alkenyloxy, nitro, amino, lower alkylamino, lower alkanoylamino or N-heterocyclyl;
- R.sub.4 is lower alkoxy;
- R.sub.5 is hydrogen, lower alkyl, lower alkenyl, lower alkoxy, lower alkenyloxy, nitro, amino, lower alkanoylamino, lower alkylamino or N-heterocyclyl;
- and R.sub.6 is alkanoyloxymethylene, alkenyloxycarbonyl, alkynyloxycarbonyl, carbamoyl, mono(lower alkyl)-carbamoyl, di(lower alkyl)-carbamoyl, N-heterocyclylcarbonyl, or alkoxycarbonyl where its alkoxy moiety is unsubstituted or substituted with alkylamino, morpholino, piperdyl, pyridyl, alkyl substituted piperidyl or alkyl substituted pyridyl,
- or pharmaceutically acceptable salts thereof.
3 more elements
A compound of the formula:
- ##STR18## wherein R.sub.1 and R.sub.2 are lower alkyl;
- R.sub.3 is hydrogen or lower alkyl;
- R.sub.4 is lower alkoxy;
- R.sub.5 is hydrogen, lower alkyl or lower alkoxy;
- and R.sub.6 is alkoxycarbonyl or carbamoyl,
- or pharmaceutically acceptable salts thereof.
3 more elements
Dependencies are inferred from the claim text.