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US 4,214,000 AGranted
Zinc salt of all-trans-retinoic acid for the treatment of acne
AssigneeJohnson & Johnson
InventorChristopher M. Papa
Life of this patent
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Abstract
A zinc salt of retinoic acid has been prepared and found to have significant anti-acne activity, similar to that of retinoic acid, but with less of a tendency to cause flaking or irritation at anti-acne effective concentrations.
Claims29
A zinc salt of all-trans-retinoic acid having the theoretical structural formula:
- ##STR2## and a zinc content of about 7.1 to 8.5 weight percent.
A topical composition for the treatment of acne comprising a therapeutically effective concentration of a zinc salt of all-trans-retinoic acid in a pharmaceutically acceptable topical vehicle compatible therewith, said zinc salt having the theoretical structural formula:
- ##STR3## and a zinc content of about 7.1 to 8.5 weight percent.
Dependencies are inferred from the claim text.