Anthracycline antibiotics
AssigneeZaidan Hojin Biseibutsu Kagaku Kenkyu Kai
InventorsHamao Umezawa, Tomio Takeuchi, Toshikazu Oki, Taiji Inui
Life of this patent
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Abstract
New anthracycline glycosides designated MA 144-G1, -G2, -L, -S1, -N1, -U1 and -Y which inhibit the growth of gram-positive bacteria and experimental animal tumors are produced by fermentation of certain species of Streptomyces and by the chemical or enzymatic conversion of certain anthracycline glycosides. New microbiological and chemical processes are also provided for preparation of the anthracycline glycosides MA 144-S2 and -U2 which have been found to be identical with the previously reported anthracyclines, marcellomycin and musettamycin.
Claims9
An anthracycline glycoside of the general formula ##STR15## wherein R.sup.3 is hydrogen, ##STR16## or a non-toxic acid addition salt thereof or a complex thereof with deoxyribonucleic acid.
The anthracycline glycoside MA 144-G1 of the formula ##STR17## or a non-toxic acid addition salt thereof or a complex thereof with deoxyribonucleic acid.
The anthracycline glycoside MA 144-S1 of the formula ##STR18## or a non-toxic acid addition salt thereof or a complex thereof with deoxyribonucleic acid.
The anthracycline glycoside MA 144-N1 of the formula ##STR19## or a non-toxic acid addition salt thereof or a complex thereof with deoxyribonucleic acid.
The anthracycline glycoside MA 144-U1 of the formula ##STR20## or a non-toxic acid addition salt thereof or a complex thereof with deoxyribonucleic acid.
The anthracycline glycoside MA 144-Y of the formula ##STR21## or a non-toxic acid addition salt thereof or a complex thereof with deoxyribonucleic acid.
The anthracycline glycoside MA 144-G2 of the formula ##STR22## or a non-toxic acid addition salt thereof or a complex thereof with deoxyribonucleic acid.
The anthracycline glycoside MA 144-L of the formula ##STR23## or a non-toxic acid addition salt thereof or a complex thereof with deoxyribonucleic acid.
A pharmaceutical composition comprising an effective antibacterial amount of MA 144-G1, -G2, -L, -S1, -N1, -U1 or -Y, or a non-toxic acid addition salt thereof or a complex thereof with deoxyribonucleic acid, in combination with in inert pharmaceutically acceptable carrier or diluent.
Dependencies are inferred from the claim text.