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US 4,199,569 AGranted
Selective hydrogenation products of C-076 compounds and derivatives thereof
AssigneeMerck & Co., Inc.
InventorsJohn C. Chabala, Michael H. Fisher
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Abstract
Derivatives of C-076 are described in which the C-076 molecule, as series of macrolides, has a specific unsaturation, at the 22,23-position, catalytically reduced. Further reaction of the reduced C-076 compounds are also possible. The compounds thus produced have profound anthelmintic, insecticidal, ectoparasiticidal and acaracidal activity. Compositions containing the described C-076 derivatives as the active ingredient thereof are also disclosed.
Claims20
A compound having the formula:
- ##STR4## wherein R.sub.1 is iso-propyl or sec-butyl;
- R.sub.2 is methoxy, hydroxy or loweralkanoyloxy;
- and
- R.sub.3 is hydrogen;
- loweralkanoyl;
- .alpha.-L-oleandrosyl;
- 4'-loweralkanoyl-.alpha.-L-oleandrosyl;
- 4'-(.alpha.-L-oleandrosyl)-.alpha.-L-oleandrosyl, 4"-loweralkanoyl-4'-(.alpha.-L-oleandrosyl)-.alpha.-L-oleandrosyl.
5 more elements
Dependencies are inferred from the claim text.