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US 4,198,392 AGranted
Oral compositions containing bis-biguanides with reduced staining tendencies
AssigneeThe Procter & Gamble Company
InventorPrem S. Juneja
Life of this patent
Estimating the term…
Abstract
Oral compositions such as toothpastes, mouthwashes, and the like containing particular substantive bis-biguanide compounds which inhibit the formation of plaque and caries.
Claims15
Bis-biguanide compounds of the formula ##STR3## wherein A and A' each represent a p-fluorophenyl radical;
- wherein X and X' each represent an alkylene radical containing from 1 to 3 carbon atoms;
- wherein z and z' are each 0;
- wherein R and R' are each hydrogen;
- wherein R.sub.2 and R'.sub.2 are each hydrogen;
- and wherein n is an integer from 2 to 4, and the pharmaceutically acceptable salts of said bis-biguanides.
2 more elements
1,2-bis-(N.sup.5 -p-fluorophenyl-N.sup.1 -biguanido)ethane.
An antiplaque oral composition comprising a carrier for use in the oral cavity and from about 0.01% to about 2.5% of an antiplaque agent having the formula:
- ##STR4## wherein A and A' each represent a p-fluorophenyl radical;
- wherein X and X' each represent an alkylene radical containing from 1 to 3 carbon atoms;
- wherein z and z' are each 0;
- wherein R and R' are each hydrogen;
- wherein R.sub.2 and R'.sub.2 are each hydrogen;
- and wherein n is an integer from 2 to 4;
- and the pharmaceutically acceptable salts of said antiplaque agents;
- said composition being substantially free of metal ion chelating agents and materials which form insoluble salts of said antiplaque agents.
5 more elements
A dentifrice composition comprising from about 0.5% to about 95% of a dentifrice abrasive and from about 0.1% to about 2% of an antiplaque agent having the formula:
- ##STR5## wherein A and A' each represent a p-fluorophenyl radical;
- wherein X and X' each represent an alkylene radical containing from 1 to 3 carbon atoms;
- wherein n is an integer from 2 to 4;
- wherein z and z' each are 0;
- wherein R and R' are each hydrogen;
- and wherein R.sub.2 and R'.sub.2 are each hydrogen;
- and the pharmaceutically acceptable salts of said antiplaque agents;
- said composition being substantially free of metal ion chelating agents and materials which form insoluble salts with said antiplaque agents.
5 more elements
A mouthwash composition comprising:
- (A) from about 5% to about 40% ethyl alcohol;
- (B) from about 5% to about 20% humectant;
- (C) from 0% to about 2% sudsing agent;
- (D) from about 0% to about 0.5% sweetening agent;
- (E) from 0% to about 0.3% flavoring agent;
- (F) from about 0.05% to about 1.5% of an antiplaque agent having the formula:
- ##STR6## wherein A and A' each represent a p-fluorophenyl radical;
- wherein X and X' each represent an alkylene radical containing from 1 to 3 carbon atoms;
- wherein n is an integer from 2 to 4;
- wherein z and z' each are 0;
- wherein R and R' are each hydrogen;
- and wherein R.sub.2 and R'.sub.2 are each hydrogen;
- and the pharmaceutically acceptable salts of said antiplaque agents;
- and
- (G) the balance water;
- said composition being substantially free of metal ion chelating agents and materials which form insoluble salts with the antiplaque agent.
13 more elements
A chewing gum composition comprising:
- (A) a gum base;
- (B) from about 0.01% to about 2.0% of flavoring material;
- and
- (C) from about 0.1% to about 2% of an antiplaque agent having the formula:
- ##STR7## wherein A and A' each represent a p-fluorophenyl radical;
- wherein X and X' each represent an alkylene radical containing from 1 to 3 carbon atoms;
- wherein n is an integer from 2 to 4;
- wherein z and z' each are 0;
- wherein R and R' are hydrogen;
- and wherein R.sub.2 and R'.sub.2 are each hydrogen;
- and the pharmaceutically acceptable salts of said antiplaque agents;
- said composition being substantially free of metal ion chelating agents and materials which form insoluble salts with the antiplaque agent.
9 more elements
A lozenge composition comprising:
- (A) a hard candy base;
- (B) from about 0.01% to about 2% of a flavoring material;
- and
- (C) from about 0.1% to about 2% of an antiplaque agent having the formula:
- ##STR8## wherein A and A' each represent a p-fluorophenyl radical;
- wherein X and X' each represent an alkylene radical containing from 1 to 3 carbon atoms;
- wherein n is an integer from 2 to 4;
- wherein z and z' each are 0;
- wherein R and R' are each hydrogen;
- and wherein R.sub.2 and R'.sub.2 are each hydrogen;
- and the pharmaceutically acceptable salts of said antiplaque agents;
- said composition being substantially free of metal ion chelating agents and materials which form insoluble salts with the antiplaque agent.
9 more elements
Dependencies are inferred from the claim text.