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US 4,195,128 AGranted
Polymeric carrier bound ligands
AssigneeBayer Aktiengesellschaft
InventorsDietrich Hildebrand, Thomas Gribnau
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Abstract
A process for bonding a ligand to a carrier through the use of a pyrimidine derivative of the formula: ##STR1## in which R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are each independently hydrogen, hydroxyl, halogen, lower alkyl, lower alkoxy, loweralkylthio, loweracylamino, nitro, cyano, carboxamido, loweralkylsulphonyl, loweralkoxycarbonyl, phenyl, trifluoromethyl or chloromethyl, the ligand or the carrier containing at least one functional group that reacts with the pyramidine derivative.
Claims6
A carrier bound ligand of the formula:
- T--X--P--X--L
- wherein
- T represents the residue of a polymeric carrier;
- X is independently a divalent oxygen or sulfur atom, --NH--, --NHR.sup.5 --, --CONH-- or --CONR.sup.5 --, wherein R.sup.5 is lower alkyl;
- L is the residue of a ligand;
- and
- P is ##STR13## wherein each R.sup.6 is hydrogen, hydroxyl, lower alkyl, lower alkoxy, loweralkylthio, loweracylamino, nitro, cyano, carboxamide, loweralkylsulphonyl, loweralkoxycarbonyl, phenyl, trifluoromethyl, chloromethyl or T--X--.
4 more elements
Dependencies are inferred from the claim text.