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US 4,193,931 AGranted
Polyene compounds
AssigneeHoffmann-La Roche Inc.
InventorPeter Loeliger
Life of this patent
Estimating the term…
Abstract
Novel 7-(substituted indanyl or naphthyl)-3-methyl-octa-2,4,6-triene derivatives useful as anti-tumor agents are disclosed.
Claims21
A polyene compound of the formula:
- ##STR14## wherein R.sub.1 and R.sub.2 each are hydrogen, halogen or lower alkoxy;
- R.sub.3, R.sub.4, R.sub.5 and R.sub.6 each are hydrogen or lower alkyl;
- R.sub.7 is hydroxymethyl, lower alkoxymethyl, lower alkanoyloxymethyl, carboxyl, lower alkoxycarbonyl, mono(lower alkyl)carbamoyl or di(lower alkyl)carbamoyl;
- and n is 1 or 2 or the alkali metal salts thereof.
1 more element
A pharmaceutical preparation containing a polyene compound of the formula:
- ##STR15## wherein R.sub.1 and R.sub.2 each are hydrogen, halogen atom or lower alkoxy;
- R.sub.3, R.sub.4, R.sub.5 and R.sub.6 each are hydrogen or lower alkyl;
- R.sub.7 is hydroxymethyl, lower alkoxymethyl, lower alkanoyloxymethyl, carboxyl, lower alkoxycarbonyl, mono(lower alkyl)carbamoyl or di(lower alkyl)carbamoyl group;
- and n is 1 or 2;
- in association with a compatible pharmaceutical carrier.
2 more elements
Dependencies are inferred from the claim text.