Biphenyl derivatives
AssigneeBoehringer Ingelheim GmbH
InventorsJosef Nickl, Erich Muller, Berthold Narr, Walter Haarmann, Wolfgang Schroter, Rudolf Kadatz
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AssigneeBoehringer Ingelheim GmbH
InventorsJosef Nickl, Erich Muller, Berthold Narr, Walter Haarmann, Wolfgang Schroter, Rudolf Kadatz
Estimating the term…
Compounds of the formula ##STR1## wherein R.sub.1 is hydrogen, fluorine, chlorine, bromine, methyl, methoxy, methylthio or cyano; R.sub.2 is hydrogen or fluorine; R.sub.3 is carboxyl, (alkoxy of 1 to 6 carbon atoms)-carbonyl, methoxy-(alkoxy of 1 to 6 carbon atoms)-carbonyl, (alkenyloxy of 2 to 6 carbon atoms)-carbonyl, (aralkoxy of 7 to 12 carbon atoms)-carbonyl, phenoxy-carbonyl or pyridyl-methoxy-carbonyl, A is (alkyl of 1 to 3 carbon atoms)-methylene, m is 1 or 2; and n is 0, 1, 2 or 3; and, when R.sub.3 is carboxyl, non-toxic salts thereof formed with an inorganic or organic base. The compounds as well as the salts are useful as antithrombotics, anticholesteremics and anticoagulants.
A diastereoisomer or optically active antipode of a compound of the formula ##STR5## wherein R.sub.3 is (alkoxy of 1 to 6 carbon atoms)-carbonyl.
Dependencies are inferred from the claim text.