Amide derivatives
AssigneeImperial Chemical Industries PLC
InventorAlasdair T. Glen
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Abstract
The disclosure relates to novel 3,4-disubstituted-branched-chain-fluorinated-acylanilides, processes for their manufacture and pharmaceutical compositions containing them. The compounds possess antiandrogenic activity. Representative of the compounds disclosed is 4-nitro-3-trifluoromethyl-(2-hydroxy-2-trifluoromethylpropionyl)anilide.
Claims9
An acylanilide of the formula:
- ##STR7## wherein R.sup.1 is cyano, nitro, trifluoromethyl, chloro, bromo, iodo, hydrogen or alkyl of up to 4 carbon atoms;
- wherein R.sup.2 is cyano, nitro, trifluoromethyl, chloro, bromo or iodo;
- wherein R.sup.3 is hydrogen or alkyl of up to 4 carbon atoms;
- wherein R.sup.4 is alkyl of up to 4 carbon atoms;
- wherein R.sup.5 is trifluoromethyl, difluoromethyl or monofluoromethyl;
- and wherein R.sup.6 is hydrogen, hydroxy, halogen, alkyl or alkoxy each of up to 4 carbon atoms, arylalkoxy of up to 10 carbon atoms or alkanoyloxy of up to 15 carbon atoms.
The compound 3,4-dicyano-(2-hydroxy-2-trifluoromethylpropionyl)anilide, 3-chloro-4-nitro-(2-hydroxy-2-trifluoromethylpropionyl)anilide or 3,4-dichloro-(2-hydroxy-2-trifluoromethylpropionyl)anilide.
The compound 4-nitro-3-trifluoromethyl-(2-hydroxy-2-trifluoromethylpropionyl)anilide.
The compound 4-cyano-3-trifluoromethyl-(2-hydroxy-2-trifluoromethylpropionyl)anilide.
Dependencies are inferred from the claim text.