Polymeric agent for releasing 5-aminosalicylic acid or its salts into the gastrointestinal tract
AssigneeDynapol
InventorsThomas M. Parkinson, Joseph P. Brown, Robert E. Wingard, Jr.
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Abstract
A generic polymeric agent for releasing 5-aminosalicylic acid or its salts is disclosed which comprises a nonabsorbable pharmacologically acceptable organic polymer backbone containing aromatic rings to which are covalently bonded via azo bonds a plurality of salicylic acid or salicylate salt groups. The azo bonds attach to the salicylates' 5-position carbon. The polymers undergo bacterial cleavage in the mammalian lower bowel to release 5-aminosalicylic acid and/or its salts.
Claims10
A polymeric compound which comprises a pharmacologically acceptable organic polymer backbone comprising a plurality of aromatic rings and having a molecular size which precludes the backbone's absorption from the intestinal lumen and a plurality of salicylic acid or salicylate salt groups covalently bonded to said backbone via azo groups that are intermediate backbone aromatic carbons and salicylic acid or salicylate salt 5-position carbons.
Dependencies are inferred from the claim text.