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US 4,189,597 AGranted
11-(2-Hydroxyethylthio)prostenoic acid E series derivatives
AssigneeAmerican Cyanamid Company
InventorsMartin J. Weiss, Gerald J. Siuta
Life of this patent
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Abstract
This disclosure describes certain 11-(2-hydroxyethylthio)-9-keto-prostenoic acid E series derivatives, and their intermediates, useful as bronchodilators and inflammatory medeator release inhibitors.
Claims5
An optically active compound of the formula:
- ##STR44## wherein Z is --(CH.sub.2).sub.6 --;
- R.sub.1 is selected from the group consisting of hydroxy and C.sub.1-C.sub.6 alkoxy;
- and R is a moiety selected from the group consisting of ##STR45## wherein R.sub.4 is selected from the group consisting of hydrogen and methyl, R.sub.5 is selected from the group consisting of C.sub.4 -C.sub.7 alkyl, R.sub.6 is selected from the group consisting of C.sub.3 -C.sub.5 alkyl, R.sub.8 is selected from the group consisting of C.sub.1 -C.sub.2 alkyl, and R.sub.11 is selected from the group consisting of C.sub.3 -C.sub.7 alkyl;
- the racemic mixture thereof;
- the mirror image thereof;
- and when R.sub.1 is hydroxy, the pharmaceutically acceptable salts thereof, with the proviso that the substituent at the carbon-11 position is .beta.-(2-hydroxyethylthio).
3 more elements
An optically active compound that is methyl nat. 11.alpha.-(2-hydroxy-ethylthio)-15.alpha.-hydroxy-16, 16-trimethylene-9-oxo-13-trans-prostenoate.
Dependencies are inferred from the claim text.