Antihypertensive 4-amino-2-[4-(1,4-benzodioxan-2-carbonyl) piperazin-1-yl or homopiperazin-1-yl]quinazolines
AssigneePfizer Inc.
InventorSimon F. Campbell
Life of this patent
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Abstract
Compounds having the formula ##STR1## and pharmaceutically acceptable salts thereof wherein R represents 6,7-di(lower alkoxy) or 6,7,8-tri(lower alkoxy); m is 1 or 2, X is --CHR.sup.1 -- or --CH.sub.2 CH.sub.2 --; each R.sup.1 and R.sup.0 may be the same or different and is hydrogen or lower alkyl; each of R.sup.2 and R.sup.3 is hydrogen, lower alkoxy, lower alkyl, halogen, lower alkanoyl, lower alkoxycarbonyl, --CONR.sup.4 R.sup.5 or --SO.sub.2 NR.sup.4 R.sup.5 wherein each of R.sup.4 and R.sup.5 is hydrogen or lower alkyl; processes for their preparation; and their use as regulators of the cardiovascular system, and particularly in the treatment of hypertension.
Claims6
A compound of the formula ##STR38## wherein (R).sub.n is selected from the group consisting of 6,7-di(lower alkoxy) or 6,7,8-tri(lower alkoxy);
- m is 1 or 2;
- X is selected from the group consisting of --CHR.sup.1 -- or --CH.sub.2 CH.sub.2 --;
- each of R.sup.1 and R.sup.0 is selected from the group consisting of hydrogen or lower alkyl;
- and R.sup.2 and R.sup.3, which may the same or different, are selected from the group consisting of hydrogen, lower alkyl, lower alkoxy, halogen, lower alkanoyl, lower alkoxycarbonyl or a group of the formula --CONR.sup.4 R.sup.5 or --SO.sub.2 NR.sup.4 R.sup.5 wherein R.sup.4 and R.sup.5, which may the same or different, are selected from the group consisting of hydrogen or lower alkyl;
- and the pharmaceutically acceptable acid addition salts thereof.
Dependencies are inferred from the claim text.