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US 4,187,381 AGranted
16-Substituted prostaglandins
AssigneeHoffmann-La Roche Inc.
InventorsGeorge W. Holland, Jane L. Jernow, Perry Rosen
Life of this patent
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Abstract
A process for producing optically active 16-substituted prostaglandins and new 16-substituted prostaglandins produced thereby which are useful as cardiovascular agents and as agents for inducing labor in pregnant females and for the termination of pregnancy.
Claims4
A compound of the formula:
- ##STR44## wherein R.sub.4 is hydrogen or lower alkyl;
- R.sub.1 is lower alkyl;
- R.sub.6 is hydroxy, lower alkanoyloxy, benzoyloxy, tetrahydropyranyloxy, benzyloxy, benzhydryloxy, trimethylsilyloxy, trityloxy or 4-methoxy-5,6-dihydro-2H-pyranyloxy;
- or enantiomers or racemates thereof.
1 more element
Dependencies are inferred from the claim text.