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US 4,182,752 AGranted
Neocarzinostatin derivatives and a process for producing the same
AssigneeKayaku Antibiotic Research Co., Ltd.
InventorsHiroshi Maeda, Ryunosuke Kanamaru, Nakao Ishida
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Abstract
Neocarzinostatin derivatives having the formula; ##STR1## wherein N represents a neocarzinostatin residue, and R.sub.1 +R.sub.2 represents a residue of polystyrene-maleic acid copolymer having a molecular weight of 2,500 to 80,000. These neocarzinostatin derivatives are prepared by reacting neocarzinostatin with a polystyrene-maleic acid copolymer containing at least one maleic anhydride residue per molecule. The neocarzinostatin derivatives exhibit anticarcinogenic activity.
Claims3
A neocarzinostatin derivative of the formula:
- ##STR4## Wherein N represents a neocarzinostatin nucleus, and R.sub.1 --CH(CO-)CH(COOH)--R.sub.2 represents a polystyrene-maleic acid copolymer, said neocarzinostatin derivative being separable into high and low molecular weight fractions having acute toxicities in rats of about 1/50 and about 1/10 respectively in comparison to neocarzinostatin.
Dependencies are inferred from the claim text.