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AssigneeBoehringer Mannheim GmbH
InventorsJurgen Horn, Winfried Albert, Hans-Georg Batz, Michael Nelbock-Hochstetter
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Biologically active protein compositions comprising protein or a protein substrate bound onto a polyamide of the general formula: ##STR1## in which R and R.sub.1, which may be the same or different, are polyamide residues bound onto the amido group, R.sub.2 is the residue of a compound which can be condensed with formaldehyde and which contains at least one further reactive group, R.sub.3 is the residue of a bi- or poly-functional protein reagent, n is 0 or 1, and P is a biologically active protein; these compositions are obtainable by the reaction of a polyamides with amounts, equimolar to one another, of formaldehyde and of a compound condensable with formaldehyde, in a solvent for polyamides, reacting the product thereby obtained with a bi- or poly-functional protein reagent and coupling the resulting reaction product with the biologically active protein or protein substrate.
Biologically active protein composition comprising protein or a protein substrate bound onto a polyamide, of the formula ##STR4## in which R and R.sub.1, which may be the same or different, are polyamide residues bound onto the amido group,
Process for fixing a biologically active protein composition comprising a protein or a protein substrate onto a polyamide which process comprises reacting the polyamide, in the presence of a solvent for polyamides, with amounts, equimolar to one another, of formaldehyde and of a compound which can be condensed with formaldehyde and contains at least one further reactive group, to result in the formation of a polyamide derivative of the formula ##STR5## wherein R and R.sub.1, which are the same or different, are polyamide residues bound onto the amido group, and
Dependencies are inferred from the claim text.