Polyanion-stabilized aluminum hydrogels
OwnerNorbert S. Mason, Robert E. Sparksinventors
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Abstract
Aluminum hydrogels which are stabilized at pH below 7 with a polymer containingcarboxyl groups, e.g., carboxy methyl cellulose or gum arabic. The gels are useful as phosphate binding agents in the treatment of hyperphosphatemia. Such polymers are incorporated during the formation of the aluminum hydrogel, permitting a high yield to be obtained, and preventing colloidal sol formation during exchange with monovalent anions.
Claims15
A non-astringent phosphate binding agent having a high phosphate binding capacity which capacity is maintained upon dehydration comprising a stabilized hydrogel of an aluminum salt and a carboxy-containing polymeric anion having a molecular weight of from 1,000 to 700,000, with the hydrogel formed at a pH below about 7.
Dependencies are inferred from the claim text.