Benzoylphenoxy propionic acid, esters thereof and pharmaceutical composition
AssigneeOrchimed S. A.
InventorAndre Mieville
Life of this patent
Estimating the term…
Abstract
Compounds of the formula ##STR1## in which A is lower alkyl, or a substituted or unsubstituted phenyl, thienyl, furyl, indolyl or thiaindolyl radical, R, X.sub.4 and X.sub.5 are hydrogen or lower alkyl, Y is hydrogen, hydroxy, etherified hydroxy, substituted amino, or N-attached heterocyclyl, X.sub.0 is O or OCH.sub.2 CH.sub.2 O, R' represents hydrogen, lower alkyl or acetyl; and acid-addition salts thereof, are novel and useful in pharmacy as hypolipaemiant, hypocholosterolaemiant and cholagogic agents or in the preparation of such agents.
Claims6
A compound of the formula:
- ##STR226## wherein A represents 2-methylphenyl, 2,6-dimethylphenyl, 4-ethylphenyl, 4-methoxyphenyl, 3,4,5-trimethoxyphenyl, 4-nitrophenyl, 4-aminophenyl, 4-trifluoromethylphenyl, 3-trifluoromethylphenyl or 4-chloro-3-methoxyphenyl;
- R, X.sub.4 and X.sub.5 are the same or different and represent hydrogen or C.sub.1-4 alkyl;
- Y represents OH or C.sub.1-12 alkoxy;
- and
- X.sub.o represents oxygen if Y is OH or represents oxygen or the --O--CH.sub.2 --CH.sub.2 --O--group if Y is C.sub.1-12 alkoxy;
- or an acid addition thereof.
Diethylaminoethyl 2-[(4-benzoyl)-phenoxy]-2-methylpropionate.
Isopropyl 2-[4-(p-hydroxybenzoyl)-phenoxy]-2-methylpropionate.
Isopropyl 2-[4-(p-nitrobenzoyl)-phenoxy]-2-methylpropionate.
Dependencies are inferred from the claim text.