Sulphated ion exchanger and method for preparation thereof
AssigneeDevelopment Finance Corporation of New Zealand
InventorsJohn S. Ayers, David R. Husbands
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Abstract
The invention relates to a novel sulphated cationic ion exchanger and to a method for preparation thereof. In addition it relates to a method of improving the capacity of an exchange matrix to receive sulphated groups. Although the general attraction of sulphate groups to proteins is known we have found that sulphated ion exchangers selectively bind lipoproteins in blood serum or plasma under suitable conditions. We have also discovered that when hydroxyalkyl groups are introduced into the ion exchanger matrix its capacity for taking up sulphate groups is unexpectedly increased. A method of use of the ion exchanger is also described.
Claims16
A cationic ion exchanger comprising a water insoluble hydrophilic, water swellable matrix;
- a plurality of sulphate groups chemically bonded to said matrix, the ion exchange capacity of said exchanger being provided by said sulphate groups;
- said matrix being a member selected from the group consisting of:
- (a) a cross-linked carbohydrate, and,
- (b) a cross-linked carbohydrate having a plurality of hydroxy C.sub.a -C.sub.4 alkyl groups chemically bonded thereto.
A process for the preparation of a cationic ion exchanger which comprises the steps of:
- hydroxy C.sub.2 -C.sub.4 alkylating a water insoluble, hydrophilic water swellable cross-linked cellulose selected from the group consisting of native fibrous, microgranular, microcrystalline and regenerated cellulose, said cellulose being further selected from the group consisting of unsubstituted cellulose and cellulose substituted by hydroxy C.sub.2 -C.sub.4 alkyl groups;
- and
- sulphating the product of step 1.
Dependencies are inferred from the claim text.