Process for the preparation of thienopyridine derivatives

Process for the preparation of compounds having the general formula:

• ##STR17## in which R.sub.1 is a member selected from the group consisting of C.sub.1-7 alkyl;
• phenyl lower alkylene, phenyl lower alkylene in which the phenyl is substituted with 1 to 3 substituents selected from the group consisting of lower alkyl, hydroxy, lower acyloxy, lower alkoxy, nitro and halogen;
• naphthyl lower alkylene;
• thienyl lower alkylene;
• diphenyl lower alkylene;
• phenyl hydroxy-lower-alkylene;
• phenyl hydroxy-lower-alkylene in which the phenyl is substituted with 1 to 3 substituents selected from the group consisting of lower alkyl, hydroxy, lower acyloxy, lower alkoxy, nitro and halogen;
• naphthyl hydroxy-lower-alkylene;
• thienyl hydroxy-lower-alkylene;
• and diphenyl hydroxy-lower-alkylene;
• R.sub.2 is selected from the group consisting of hydrogen and lower alkyl;
• R.sub.3 is hydrogen;
• and R.sub.4 is hydrogen, comprising reacting a compound having the formula:
• ##STR18## in which R.sub.1, R.sub.2 and R.sub.3 are as defined above, with a compound having the formula:
• ##STR19## in which R.sub.4 is as defined above;
• X is a radical selected from the group consisting of halogen, amino and substituted amino;
• and Y represents a radical selected from the group consisting of lower alkoxy, substituted lower alkoxy, thio(lower)alkyl, substituted thio(lower)alkyl, amino, substituted amino, and a group of the formula:
• ##STR20## in which R is a radical selected from lower alkyl, or both the groups X and Y, together with the carbon atom to which they are attached, form a 6-membered nucleus selected from hexahydro-S--triazinic and trioxannic heterocyclic nucleus, in an inert solvent, at a temperature between 0.degree. and 150.degree. C. and in an anhydrous medium.