Deoxynarasin antibiotics
AssigneeEli Lilly and Company
InventorsWalter M. Nakatsukasa, Gary G. Marconi, Norbert Neuss, Robert L. Hamill
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Abstract
Deoxynarasin antibiotic complex, comprising 20-deoxynarasin and 20-deoxy-epi-17-narasin, is produced by submerged aerobic fermentation of Streptomyces aureofaciens NRRL 11181. 20-Deoxynarasin and 20-deoxy-epi-17-narasin are separated and isolated by chromatography. The deoxynarasin complex, 20-deoxynarasin and 20-deoxy-epi-17-narasin are antibacterial and anticoccidial agents and also increase feed-utilization efficiency in ruminants. 20-Deoxynarasin and its salts are cardiotonic agents.
Claims27
The method of enhancing the contractile force of mammalian heart muscle in a warm-blooded mammal which comprises administering parenterally an effective nontoxic dose of between approximately 30 and 500 mcg/kg of body weight of a compound selected from 20-deoxynarasin and its pharmaceutically acceptable salts.
A method of increasing feed-utilization efficiency in ruminant animals which comprises orally administering to such animals an effective propionate-increasing amount of a member selected from the group consisting of (1) 20-deoxynarasin and its pharmaceutically acceptable salts, (2) 20-deoxy-epi-17-narasin and its pharmaceutically acceptable salts, and (3) deoxynarasin antibiotic complex.
A feed composition adapted to fatten cattle comprising cattle feed and from 1 to 30 g per ton of a member selected from the group consisting of (1) 20-deoxy-narasin and its pharmaceutically acceptable salts, (2) 20-deoxy-epi-17-narasin and its pharmaceutically acceptable salts, and (3) deoxynarasin antibiotic complex.
A method of preventing or treating coccidiosis in poultry which comprises administering to poultry an effective anticoccidial amount of a member selected from the group consisting of (1) 20-deoxynarasin and its pharmaceutically acceptable salts, (2) 20-deoxy-epi-17-narasin and its pharmaceutically acceptable salts, and (3) deoxynarasin antibiotic complex.
A feed composition for poultry comprising poultry feed and an anticoccidial amount of a member selected from the group consisting of (1) 20-deoxynarasin and its pharmaceutically acceptable salts, (2) 20-deoxy-epi-17-narasin and its pharmaceutically acceptable salts, and (3) deoxynarasin antibiotic complex.
A method for the control of swine dysentery which comprises orally administering to swine an amount which is effective to control swine dysentery of a member selected from the group consisting of (1) 20-deoxynarasin and its pharmaceutically acceptable salts, (2) 20-deoxy-epi-17-narasin and its pharmaceutically acceptable salts, and (3) deoxynarasin antibiotic complex.
A feed composition for swine comprising swine ration and an amount which is effective to control swine dysentery of a member selected from the group consisting of (1) 20-deoxynarasin and its pharmaceutically acceptable salts, (2) 20-deoxy-epi-17-narasin and its pharmaceutically acceptable salts, and (3) deoxynarasin antibiotic complex.
Dependencies are inferred from the claim text.