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US 4,173,571 AGranted
13-Halo and 13-deoxy derivatives of C-076 compounds
AssigneeMerck & Co., Inc.
InventorsJohn C. Chabala, Michael H. Fisher, Helmut H. Mrozik
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Abstract
Derivatives of the C-076 compounds are disclosed wherein the 13-position is unsubstituted. The compounds are prepared by removing the glycosyl groups on the 13-position of the C-076 compounds isolated from the fermentation broth of Streptomyces avermitilis, followed by halogenation and subsequent removal of the halogen. The disclosed compounds are antiparasitic, anthelmintic, insecticidal and acaricidal agents.
Claims18
A compound having the formula:
- ##STR4## wherein the broken line indicates a single or a double bond;
- R.sub.1 is hydrogen or halogen;
- R.sub.2 is hydrogen, methyl or loweralkanoyl;
- R.sub.3 is n-propyl or sec-butyl;
- and
- R.sub.4 is present only when the broken line indicates a single bond and represents hydrogen, hydroxy, loweralkanoyloxy, loweralkylthio, loweralkylsulfinyl, loweralkylsulfonyl or loweralkoxy;
- provided that when R.sub.2 is hydrogen or methyl the broken line can indicate only a single bond and R.sub.4 is other than hydroxy.
4 more elements
Dependencies are inferred from the claim text.