Polyamine compounds
AssigneeMerck & Co., Inc.
InventorsRichard A. Dybas, Nathaniel Grier, Bruce E. Witzel
Life of this patent
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Abstract
Novel diphenyl and loweralkyl substituted diphenyl polyamines are useful antimicrobial agents, as well as algae inhibitors. They are especially useful because of their low toxicity, and as such are advantageously included as the active agent in surgical scrubs, antibacterial soaps, as preservatives in cosmetic preparations, and the like. They also can be used for topical treatment of dermatological conditions having a bacterial origin or implication such as Acne vulgaris.
Claims22
A compound of the formula:
- ##STR10## where R is hydrogen or loweralkyl;
- each R.sub.1 is alike or different and is C.sub.1 to C.sub.4 alkylene;
- ##STR11## and R.sub.2 is 2-hydroxy-1,3-trimethylene, or R.sub.1 as previously defined;
- R.sub.3 is hydrogen, C.sub.1 to C.sub.4 alkyl, C.sub.2 to C.sub.4 aminoalkyl, C.sub.1 to C.sub.4 hydroxyalkyl, or C.sub.2 to C.sub.4 dihydroxyalkyl;
- R.sub.4 is 2-hydroxy-1,3-trimethylene, or R.sub.1 as previously defined;
- R.sub.5 is hydrogen, aminoethyl, aminopropyl, C.sub.1 to C.sub.4 hydroxyalkyl, or C.sub.2 to C.sub.4 dihydroxyalkyl;
- and
- R.sub.6 is hydrogen, C.sub.1 to C.sub.4 hydroxyalkyl or C.sub.2 to C.sub.4 dihydroxyalkyl.
A compound of the formula:
- ##STR14## where each A is alike or different and is ##STR15## each R is alike or different and is hydrogen or loweralkyl;
- R.sub.1 is methylene, ethylene, trimethylene or tetramethylene;
- and where Z is:
- --(CH.sub.2).sub.3 NH(CH.sub.2).sub.3 NH.sub.2 ;
- --(ch.sub.2).sub.2 nh(ch.sub.2).sub.2 nh(ch.sub.2).sub.2 nh.sub.2 ;
- --(ch.sub.2).sub.3 nch.sub.3 (ch.sub.2).sub.3 nh.sub.2 ;
- --ch.sub.2 chohch.sub.2 nh.sub.2 ;
- --(ch.sub.2).sub.2 nh.sub.2 ;
- --(ch.sub.2).sub.3 nh.sub.2 ;
- and acid addition salts thereof.
The compound 1-[1,5-di-(4-t-butylphenyl)-3-pentyl]-1,5,9-triazanonane and its trihydrochloride salt.
Dependencies are inferred from the claim text.