1 And 2-substituted analogues of certain prostaglandins
AssigneeMiles Laboratories, Inc.
InventorsWilliam G. Biddlecom, Harold C. Kluender, Warren D. Woessner
Life of this patent
Estimating the term…
Abstract
Disclosed are trans 1 & 2-di(loweralkyl)phosphono; 1 & 2-chloro, bromo and iodo; 1 & 2-thio and 1 & 2-amino analogues of E.sub.1, A.sub.1, F.sub.1.alpha., F.sub.1.beta., 11 deoxy E.sub.1, 11 deoxy F.sub.1.beta., and 11 deoxy F.sub.1.alpha. prostaglandins. The prostaglandins of this invention are variously useful as antithrombic agents, bronchodilators such as in the treatment of asthma, inhibitors of gastric secretion and as antihypertensive agents. Certain of the prostaglandins disclosed herein are useful as precursors for prostaglandins having one or more of the foregoing utilities.
Claims8
Trans, 1&2-di(loweralkyl)phosphono analogues of E.sub.1, A.sub.1, F.sub.1.alpha., F.sub.1.beta., 11-deoxy-E.sub.1, 11-deoxy-F.sub.1.alpha., and 11-deoxy F.sub.1.beta. prostaglandins represented by the structural formula:
- ##STR75## wherein n is 6 or 7, M is H or OH;
- A is ##STR76## R' is methyl, ethyl, propyl or butyl;
- and R is (CH.sub.2).sub.3 CH.sub.3, (CH.sub.2).sub.4 CH.sub.3, CH.sub.3, cyclohexyl, ##STR77## (CH.sub.2).sub.2 CH.sub.3 or (CH.sub.2)CH.sub.3.
Dependencies are inferred from the claim text.