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US 4,171,318 AGranted
Fluorinated polyenes
AssigneeHoffmann-La Roche Inc.
InventorsKa-Kong Chan, Beverly A. Pawson
Life of this patent
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Abstract
9-Substituted, 4- or 6-fluorine substituted retinoic acid derivatives useful as antitumor agents and in the treatment of acne as well as a method for their manufacture are disclosed. Substituents at the 9-position include substituted phenyl, thienyl and furyl groups.
Claims20
A compound having the formula:
- ##STR50## wherein one of R.sub.1 and R.sub.2 is fluorine and the other is hydrogen;
- R.sub.3 is formyl, hydroxymethyl, alkoxymethyl, carboxyl, alkoxycarbonyl, carbamoyl, mono(lower alkyl)-carbamoyl or di(lower alkyl)carbamoyl;
- at least one of R.sub.4, R.sub.5 and R.sub.7 is halogen and the others are hydrogen or lower alkyl;
- and R.sub.6 is lower alkyl or lower alkoxy;
- or pharmaceutically acceptable salts thereof.
2 more elements
Dependencies are inferred from the claim text.