Hemoperfusion adsorbents
AssigneeKuraray Co., Ltd.
InventorsToshihide Nakashima, Koichi Takakura
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Abstract
A hemoperfusion adsorbent is provided comprising an adsorbent material containing at least one coating thereon of a hydrophilic polymer prepared by the polymerization of at least one monomeric acrylate or methacrylate with a copolymerizable monomer containing an epoxy moiety therein. In addition, a method is provided for removing air bubbles from such adsorbents comprising boiling said adsorbents in water or physiological saline, cooling said adsorbents, packing said adsorbents into a container and sterilizing the packed container by autoclaving.
Claims7
A hemoperfusion adsorbent comprising an adsorbent material containing at least one coating thereon of a hydrophilic polymer prepared by the polymerization of at least one monomeric acrylate or methacrylate represented by the formula:
- ##STR3## wherein Y is a radical selected from the group consisting of --R.sub.2 --OR.sub.3 and --R.sub.2 --NR.sub.3 R'.sub.3, R.sub.1 is hydrogen or methyl, R.sub.2 is a divalent alkylene radical containing 2 to 3 carbon atoms or a poly(oxyalkylene) radical, and R.sub.3 and R'.sub.3, respectively, are hydrogen or an alkyl group containing 1 to 3 carbon atoms which can be substituted with polar radicals, with a copolymerizable monomer containing an epoxy moiety therein represented by the formula:
- ##STR4## wherein Z is a divalent radical selected from the group consisting of --COO--R.sub.2 -- and --CH.sub.2 --OCH.sub.2 --, n is 0 or 1, R.sub.1, R'.sub.1 and R".sub.1 are each, respectively, hydrogen or methyl and R.sub.2 is a divalent alkylene radical containing 1 to 3 carbon atoms or a poly(oxyalkylene) radical, wherein the feed ratio of the copolymerizable monomer containing an epoxy moiety therein in the polymerization ranges from 0.1 to 10% based on the weight of total monomers.
Dependencies are inferred from the claim text.