Composition of matter and process
AssigneeThe Upjohn Company
InventorsLadislav J. Hanka, David G. Martin
Life of this patent
Estimating the term…
Abstract
Novel antibiotic CC-1065 producible in a fermentation under controlled conditions using the new microorganism Streptomyces zelensis, NRRL 11,183. This antibiotic is active against Gram-positive bacteria, for example, Staphylococcus aureus, Bacillus subtilis, Streptococcus pyogenes, Sarcina lutea, and Streptococcus faecalis. It is also active against Gram-negative bacteria, for example, Escherichia coli, Proteus vulgaris, Pseudomonas aeruginosa, Klebsiella pneumoniae, and Salmonella pullorum. Thus, antibiotic CC-1065 can be used in various environments to eradicate or control such bacteria.
Claims5
Antibiotic CC-1065 which is active against Gram-positive and Gram-negative bacteria, and which in its essentially pure form has the following characteristics:
- (a) molecular weight of approximately 700;
- (b) has the following elemental analysis:
- C, 61.06;
- H, 4.92;
- N, 13.17;
- (c) is soluble in dimethylsulfoxide, dimethylformamide, acetone, methylene chloride, ethyl acetate and dioxane;
- (d) has a characteristic infrared absorption spectrum when dissolved in a mineral oil mull as shown in FIG. 1 of the drawings;
- (e) has a characteristic NMR spectrum as shown in FIG. 2 of the drawings;
- and,
- (f) has a characteristic proton spectrum as shown in FIG. 3 of the drawings.
A process for preparing antibiotic CC-1065 which comprises cultivating Streptomyces zelensis, having the identifying characteristics of NRRL 11,183, in an aqueous nutrient medium under aerobic conditions until substantial antibiotic CC-1065 activity is imparted to said medium.
A process for recovering antibiotic CC-1065 from a fermentation beer which comprises extraction of the filtered beer with a solvent for antibiotic CC-1065, and recovering antibiotic CC-1065 from said extracts.
Dependencies are inferred from the claim text.