Cis-platinum (II) complex of trans-l-1,2-diaminocyclohexane

Abstract

Cis-platinum (II) complexes of 1,2-diaminocyclohexanes, more particularly, cis-platinum (II) complexes represented by the general formula ##STR1## wherein the stereoisomerism of 1,2-diaminocyclohexane is cis-, trans-d- or trans-l-; and R.sup.1 and R.sup.2, which are same, each represent a halogen atom, or R.sup.1 and R.sup.2, when taken together, represent a group represented by the formula ##STR2## wherein R.sup.3 represents a >CH.sub.2 group, a >CHCH.sub.3 or >CHCH.sub.2 CH.sub.3 group are disclosed. Further complexes of uracil and cis-[platinum(II)-cis-, trans-d or trans-l- 1,2-diaminocyclohexane] are disclosed. These complexes have anti-tumor activity in mice. Cis-platinum (II) complex of cis-1,2-diaminocyclohexane is most effective.

Dependencies are inferred from the claim text.