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US 4,168,300 AGranted
Method of removal of hepatitis virus
AssigneeAB Kabi
InventorsLars-Olov Andersson, Hakan G. Borg, Gudrun M. Einarsson
Life of this patent
Estimating the term…
Abstract
Hepatitis virus is removed from a biological material contaminated with the virus by contact with a preparation. The preparation may be agarose gel or beaded polyacrylamide plastic coupled with a variety of hydrophobic ligands.
Claims18
A method for removing hepatitis virus from a biological material contaminated with said virus, comprising the step of bringing said hepatitis virus contaminated material in contact with a preparation which is composed of a water-insoluble, water-permeable, cross-linked gel-matrix substance selected from
- (a) a high molecular weight water-insoluble, water-permeable adsorbent, gel-matrix-forming carbohydrate of at least 1,000 molecular weight inert to ethanol, dioxane, dimethylformamide, sodium hydroxide at pH up to about 8, 0.5 M Na.sub.2 CO.sub.3 solution, acetic acid at pH 4, and 1 M NaCl, and
- (b) a beaded polyacrylamide plastic;
- and onto which gel-matrix substance, directly or through a divalent molecule extender group selected from cysteamine, propylene, and an alkylene diamine having from 2 to about 6 carbons in the alkylene chain, there is coupled a hydrophobic ligand selected from the alkylamino groups from octylamino to octadecylamino, and the dodecyl-2-amino and the caprylhydrazido groups through the amino nitrogen of the alkylamino group or the caprylhydrazido group respectively, heptanoic acid, an alkyl succinic acid from octylsuccinic acid to dodecylsuccinic acid, naphthylacetic acid, and cholesterol hydrogen succinate.
Dependencies are inferred from the claim text.