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US 4,168,267 AGranted
Phosphinylalkanoyl prolines
AssigneeE. R. Squibb & Sons, Inc.
InventorEdward W. Petrillo, Jr.
Life of this patent
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Abstract
New phosphinylalkanoyl prolines which have the general formula ##STR1## wherein R.sub.1 is lower alkyl, phenyl or phenyl-lower alkyl; R.sub.2 is hydrogen, phenyl-lower alkyl or a metal ion; R.sub.3 is hydrogen or lower alkyl; R.sub.4 is hydrogen, lower alkyl, phenyl-lower alkyl or a metal ion; and N is 0 or 1, Are useful as hypotensive agents.
Claims24
A compound of the formula ##STR18## wherein R.sub.1 is lower alkyl, phenyl or phenyl-lower alkyl;
- R.sub.2 is hydrogen, phenyl-lower alkyl or monovalent metal ion;
- R.sub.3 is hydrogen or lower alkyl;
- R.sub.4 is hydrogen, lower alkyl, phenyl-lower alkyl or monovalent metal ion;
- and n is 0 or 1.
1 more element
Dependencies are inferred from the claim text.