Synthesis of 2-keto-1,4-diazacycloalkanes
AssigneeThe B. F. Goodrich Company
InventorJohn T. Lai
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Abstract
Several novel syntheses have been discovered for preparation of 2-keto-1,4-diazacycloalkanes and their derivatives. Trans isomers of polysubstituted quinoxalin-2-ones may now be prepared.
Claims3
A method for preparing a polysubstituted 2-keto-1,4-diazacycloalkane compound comprising reacting a diamine selected from the group consisting of an acyclic 1,2-diamine and a cyclic 1,2-diamine with a cyanohydrin selected from the group consisting of an acyclic cyanohydrin and a cyclic cyanohydrin, in the presence of (i) aqueous alkali (ii) an onium salt selected from the group consisting of the ternary salts of Group VIA elements and the quaternary salts of Group VA elements, and, (iii) a haloform selected from the group consisting of bromoform and chloroform;
- forming said polysubstituted 2-keto-1,4-diazacycloalkane compound;
- and, recovering said compound.
Dependencies are inferred from the claim text.