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US 4,165,331 AGranted
11-(2-Hydroxyethylthio)prostenoic acid E series derivatives
AssigneeAmerican Cyanamid Company
InventorsMartin J. Weiss, Gerald J. Siuta
Life of this patent
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Abstract
This disclosure describes certain 11-(2-hydroxyethylthio)-9-keto-prostenoic acid E series derivatives, and their intermediates, useful as bronchodilators and inflammatory medeator release inhibitors.
Claims9
A compound of the formula:
- ##STR43## wherein Z is a divalent moiety selected from the group consisting of -(CH.sub.2).sub.6 - and ##STR44## R.sub.1 is selected from the group consisting of hydroxy;
- C.sub.1 -C.sub.6 alkoxy, trityloxy, tetrahydropyranyloxy and tri-(C.sub.1 -C.sub.6)alkylsilyloxy;
- and R.sub.2 is selected from the group consisting of hydrogen, trityl, tetrahydropyranyl and tri-(C.sub.1 -C.sub.6)alkylsilyl.
Dependencies are inferred from the claim text.