7[2(Substituted phenyl)2-(amino)acetamido]cephalosporin derivatives
AssigneeMerck Patent GmbH
InventorsRudolf Gottschlich, Rolf Gericke, Horst Juraszyk, Jurgen Seubert, Wighard Strehlow, Helmut Wahlig, Rolf Bergmann, Elvira Dingeldein
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Abstract
Novel .beta.-lactam antibiotics are compounds of the formula: ##STR1## wherein R is alkyl of up to 6 carbon atoms or, when A is oxygen, R is hydrogen; A is oxygen or --OCO--; Z is ##STR2## R.sup.1 is hydrogen, acetoxy or S-Het; Het is 1,2,3-triazol-5-yl, 1-methyltetrazol-5-yl, 1,3,4-thiadiazol-2-yl or 2-methyl-1,3,4-thiadiazol-5-yl; and n is an integer from 0 to 8; or a readily-cleavable ester or physiologically-acceptable salt thereof.
Claims5
A compound of the formula ##STR22## wherein R is alkyl of up to 6 carbon atoms or H;
- R.sup.1 is hydrogen or acetoxy;
- and n is 0 or an integer from 1 to 8;
- or a readily-cleavable ester or a pharmaceutically acceptable salt of the carboxy group thereof;
- said readily-cleavable ester being a tert-butyl, trimethylsilyl, benzyl, benzhydryl, trichloroethyl, benzylmethyl, p-methoxybenzyl, methoxymethyl or pivaloyloxymethyl ester.
Dependencies are inferred from the claim text.