Synthetic membrane for wound-dressings
AssigneeBattelle Memorial Institute
InventorDaniel Bichon
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Abstract
Artificial membrane for wound-dressings composed of two polypeptide layers, one of which at least, the inside layer which contacts the wound, is biologically resorbable and the outside layer has an asymmetric structure permeable to water and to drug solutions but pratically impervious to outside pathogenic agents. The inside layer, at least, is constituted from biodegradable copolymers of amino-acids and -diacids of which the --COOH functions are partially esterified with mono and/or di-ols.
Claims20
Synthetic membrane or skin containing poly-aminoacids usable for wound-dressings consisting of two integral layers of which at least one is resorbable by the body, the first internal layer being directly applied to the wound and the second layer constituting an external protection thereof, characterized by the fact that the second layer is formed from a porous semi-permeable membrane or film having an asymmetric structure, that is having pores of decreasing size when going from the inside layer to the outside one, which ensures the free penetration of air, water and low molecular weight substances but prevents the entrance of external pathogenic germs, and by the fact that the first layer is essentially formed of a hydrophilic, non-toxic, bio-degradable membrane or tissue consisting substantially of a pluri-cellular, spongy and fluid permeable material selected from polymers and copolymers of .alpha.-aminoacids and esters thereof.
Dependencies are inferred from the claim text.