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US 4,160,027 AGranted
Steroid cyanoketones and intermediates
AssigneeSterling Drug Inc.
InventorRobert G. Christiansen
Life of this patent
Estimating the term…
Abstract
2.alpha.-Cyano-3-oxosteroids having a 4.alpha.,5.alpha.-epoxy group and alkylated in the 4- and/or 6-position, useful as interceptive agents, are prepared by alkaline cleavage of the corresponding steroido[2,3-d]isoxazoles.
Claims22
A compound of the formula ##STR5## wherein R is hydrogen or methyl;
- R' is hydroxy or lower-alkanoyloxy;
- R" is lower-alkyl, lower-alkenyl or loweralkynyl;
- or R' and R" together represent ethylenedioxy;
- R'" is hydrogen or methyl;
- or 3-enol lower-alkanoate esters thereof;
- with the proviso that when R is hydrogen, R'" is .alpha.-methyl;
- and when R is methyl, R'" is hydrogen or .beta.-methyl.
4 more elements
4.alpha.,5.alpha.-Epoxy- 17.beta.-hydroxy-4,6.beta.-dimethyl-3-oxoandrostane-2.alpha.-carbonitrile.
A compound of the formula ##STR7## wherein:
- R is hydrogen or methyl;
- R' is hydroxy;
- R" is hydrogen, lower-alkyl, lower-alkenyl or lower-alkynyl;
- or R' and R" together represent oxo or ethylenedioxy;
- and
- R'" is hydrogen or methyl;
- with the proviso that when R is hydrogen, R'" is .alpha.-methyl;
- and when R is methyl, R'" is hydrogen or .beta.-methyl.
5 more elements
4-Methylandrosta-2,4-dieno[2,3-d]isoxazol-17-one.
4-Methyl-3,17-dioxoandrost-4-ene-2.alpha.-carbonitrile.
Dependencies are inferred from the claim text.