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US 4,159,319 AGranted
Method of preparing an attenuated transmissible gastroenteritis (TGE) virus strain for use in live vaccines
OwnerPeter A. Bachmann, Anton Mayrinventors
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Abstract
The invention relates to a method of preparing an attenuated virus strain, which can be used to protect pigs, and in particular piglets, against transmissible gastroenteritis (TGE).
Claims7
A method of preparing a vaccine containing a live, attenuated non-virulent, immunogenically active TGE virus strain, comprising isolating a virulent TGE virus strain directly on swine thyroid gland tissue, subjecting said strain to a large number of passages in said tissue to attenuate said virus while maintaining said virus immunogenically active and formulating said attenuated virus strain into a vaccine.
Dependencies are inferred from the claim text.