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US 4,156,734 AGranted
Antihypertensive compositions containing an aryl-substituted alanine azo and an arylhydrazino-propionic acid
AssigneeMerck & Co., Inc.
InventorClement A. Stone
Life of this patent
Estimating the term…
Abstract
Novel pharmaceutical compositions are disclosed. The compositions comprise an aryl substituted alanine and a substituted phenyl hydrazino propionic acid. The compositions are useful for treating hypertension.
Claims20
A pharmaceutical composition for treating hypertension comprising
- (A) a compound having the formula:
- ##STR6## wherein R.sub.1 and R.sub.2 may be hydrogen or alkyl of from 1 to 4 carbon atoms, and R.sub.3 is a substituted benzene ring having the formula:
- ##STR7## wherein Y.sub.1 is hydrogen, cyanoamino, carboxyl, cyano, thiocarbamoyl, aminomethyl, guanidino, hydroxy, methanesulfonamido, nitro, amino, methanesulfonyloxy, carboxymethoxy, formyl or methoxy and Y.sub.2 is a substituted or unsubstituted 5-membered heterocyclic ring containing one or more nitrogen, atoms, and pharmaceutically acceptable salts and hydrates thereof, and
- (B) a decarboxylase inhibitor having the formula:
- ##STR8## wherein R.sub.4, R.sub.5, R.sub.6 and R.sub.7 are independently hydrogen or C.sub.1 -C.sub.4 alkyl, and pharmaceutically acceptable salts thereof wherein the weight ration of (A):(B) is about 10:1 to about 1:100.
2 more elements
A pharmaceutical composition for treating hypertension comprising:
- (A) a mixture of D,L-4-(2-aminoimidazol-1-yl)-.alpha.-methylphenylalanine and D,L-4-(imidazol-2-yl)-.alpha.-methylphenylalanine and
- (B) a decarboxylase inhibitor having the formula:
- ##STR13## wherein R.sub.4, R.sub.5, R.sub.6 and R.sub.7 are independently hydrogen or C.sub.1 -C.sub.4 and the pharmaceutically acceptable salts thereof wherein the weight ratio of (A):(B) is about 10:1 to about 1:100.
Dependencies are inferred from the claim text.