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US 4,154,954 AGranted
11-(2-Hydroxyethylthio) prostenoic acid E series derivatives
AssigneeAmerican Cyanamid Company
InventorsMartin J. Weiss, Gerald J. Siuta
Life of this patent
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Abstract
This disclosure describes certain 11-(2-hydroxyethylthio)-9-keto-prostenoic acid E series derivatives, and their intermediates, useful as bronchodilators and inflammatory medeator release inhibitors.
Claims30
An optically active compound of the formula:
- ##STR43## wherein Z is a divalent moiety selected from the gorup consisting of -(CH.sub.2).sub.6 - and ##STR44##
- R.sub.1 is selected from the group consisting of hydroxy and C.sub.1 -C.sub.6 aloxy;
- and R is a moiety selected from the group consisting of ##STR45## wherein R.sub.6 is selected from the group consisting of C.sub.3 -C.sub.5 alkyl, R.sub.7 is selected from the group consisting of C.sub.2 -C.sub.4 alkyl, R.sub.10 is selected from the group consisting of C.sub.1 -C.sub.4 alkyl, R.sub.11 is selected from the group consisting C.sub.3 -C.sub.7 alkyl and R.sub.12 is selected from the group consisting of C.sub.1 -C.sub.3 alkyl;
- the racemic mixture thereof;
- the mirror image thereof;
- and when R.sub.1 is hydroxy, the pharmaceutically acceptable salts thereof.
3 more elements
Dependencies are inferred from the claim text.