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US 4,154,742 AGranted
Certain 5-substituted or unsubstituted phenyl or furyl benzofuran 2-carboxylic acids
AssigneeMerck & Co., Inc.
InventorsEdward J. Cragoe, Jr., Otto W. Woltersdorf, Jr., William F. Hoffman
Life of this patent
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Abstract
6,7-Disubstituted-5-(acyl)benzofuran-2-carboxylic acids, the pharmaceutically acceptable salt, ester and amide derivatives thereof and combinations of these compounds with antikaluretic agents are disclosed having diuretic-saluretic, uricosuric and antihypertensive activity.
Claims7
A compound having the formula:
- ##STR7## wherein X is halo, methyl or hydrogen;
- Y is halo or methyl and
- R is phenyl or mono or disubstituted phenyl wherein the substituent is halo, methyl, trifluoromethyl or methoxy;
- or furyl or substituted furyl wherein the substituent is halo or methyl, and
- the non-toxic pharmaceutically acceptable salt or lower alkyl ester derivative thereof.
2 more elements
A compound of the formula:
- ##STR8## wherein X is halo, methyl or hydrogen;
- Y is halo or methyl;
- R is selected from the group consisting of 2-furyl, 3-furyl, 5-methyl-2-furyl, phenyl, p-methoxy phenyl and p-chlorophenyl and
- the non-toxic pharmaceutically acceptable salt or lower alkyl ester derivative thereof.
1 more element
Dependencies are inferred from the claim text.