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US 4,152,424 AGranted
Antibiotic 1745A/X and methods for the production thereof
AssigneeHoffmann-La Roche Inc.
InventorsRichard W. Kierstead, Ronald A. LeMahieu, David Pruess
Life of this patent
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Abstract
A new antibiotic, designated as antibiotic 1745A/X, is produced by the fermentation of the known microorganism Streptomyces antibioticus, ATCC 11891, using the novel compound erythronolide A oxime as the substrate. This new antibiotic is useful an an antibacterial agent.
Claims1
Antibiotic 1745A/X characterized as follows:
- (a) melting point 146.degree.-149.degree. C.;
- (b) analysis:
- carbon, 58.69%;
- hydrogen, 9.26%;
- nitrogen, 3.45%;
- oxygen, 28.60% (by difference);
- (c) a characteristic infrared absorption spectrum as shown in accompanying FIG. 1;
- (d) a characteristic nuclear magnetic resonance spectrum as shown in accompanying FIG. 2;
- (e) a low resolution mass spectrum which shows a molecular ion at m/e 734 and major fragment peaks at 701, 649, 617, 573, 560, 546, 462, 416, 398, 251, 174, 158 and 145.
6 more elements
Dependencies are inferred from the claim text.