# US 4,152,415 A · Method of increasing the effectiveness of oral vaccination for swine dysentery

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- Number: US 4,152,415 A
- Document ID: US4152415A
- Status: Granted
- Kind: A
- Application number: 05/935,062
- Filed: 1978-08-18
- Granted: 1979-05-01
- Earliest claimed: 1978-08-18
- Assignees: Iowa State University Research Foundation, Inc.; Chromalloy American Corporation
- Inventors: Delbert L. Harris; Robert A. Goodnow
- Web page: https://patentgrep.com/patent/US4152415A

## CPC

- A61K 39/0225: {Spirochetes, e.g. Treponema, Leptospira, Borrelia}
- Y10S 424/825: Bacterial vaccine for porcine species, e.g. swine
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- Y10S: TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS

## Abstract

The resistance of field-raised swine to dysentery infection is increased by a sequence of parenteral and oral administrations. First there is parenterally administered to the swine an injectable cell concentrate containing a virulent isolate of killed cells of Treponema hyodysenteriae, and not less than five days after the animals have received the first of the parenteral injections, a series of oral administrations of enteric-coated pellets is started, the pellets containing concentrated killed cells of a virulent isolate of T. hyodysenteriae. The oral administrations are given at least once every 24 hours for a period of at least five days.

## Claims

### Claim 1

The method of increasing the resistance of field-raised swine to dysentery infection, comprising a sequence of parenteral and oral administrations which are carried out before the swine contract the infection, characterized by:
(a) first parenterally administering to the swine an injectable cell concentrate containing a virulent isolate of killed cells of Treponema hyodysenteriae at least one injection being given per animal and each injection containing at least 2 milligrams (dry basis) of said cells; and
(b) not less than 5 days after said animals have received the first of said parenteral injections beginning a series of oral administrations of enteric-coated pellets containing concentrated killed cells of a virulent isolate of Treponema hyodysenteriae, said oral administrations being given at least one every 24 hours for a period of at least 5 days, and each of said oral administrations providing at least 3 milligrams (dry basis) of said cells.

### Claim 2 (depends on 1)

The method of claim 1 in which said killed cells of Treponema hyodysenteriae are prepared from isolate B204 (ATCC No. 31287).

### Claim 3 (depends on 1, 2)

The method of claim 1 or claim 2 in which said parenteral injections comprise 2 injections per animal with an interval of at least 4 days between the days on which the injections are given, and each parenteral injection provides at least 3 milligrams (dry basis) of said cells of Treponema hyodysenteriae.

### Claim 4 (depends on 1, 2)

The method of claim 1 or claim 2 in which each of said oral administrations provide at least 4 milligrams (dry basis) of said cells per animal and are continued for at least 8 days at the rate of one oral administration per animal per 24 hours.

### Claim 5 (depends on 1, 2)

The method of claim 1 or claim 2 in which said swine are growing pigs, and said oral administrations are started after the pigs have been weaned.

### Claim 6

The method of increasing the resistance of field-raised swine to dysentery infection, comprising a sequence of parenteral and oral administrations which are carried out before the swine contract the infection, characterized by:
(a) first parenterally administering to the swine an injectable cell concentrate containing a virulent isolate of killed cells of Treponema hyodysenteriae, at least two injections being given per animal with an interval of at least 4 days between the days on which the injections are given, and each injection containing at least 2 milligrams (dry basis) of said cells; and
(b) not less than 5 days after said animals have received the first of said injections beginning the feeding of enteric-coated granules containing concentrated killed cells of a virulent isolate of Treponema hyodysenteriae, said feeding being at the rate of at least 3 milligrams (dry basis) per animal per 24-hour day, and being continued for at least 5 days.

### Claim 7 (depends on 6)

The method of claim 6 in which said cell so Treponema hyodysenteriae are prepared from isolate B204 (ATCC No. 31287).

### Claim 8 (depends on 6, 7)

The method of claim 6 or claim 7 in which said parenteral administration is intramuscular injection.

### Claim 9 (depends on 6, 7)

The method of claim 6 or claim 7 in which said swine are baby pigs, and at least the first of said parenteral administrations is given before said pigs are weaned, said feeding of said granules being started after said pigs have been weaned.

### Claim 10 (depends on 9)

The method of claim 9 in which said parenteral administration is intramuscular injection.