Method for producing maytansinol and its derivatives
AssigneeTakeda Chemical Industries, Ltd.
InventorsEiji Higashide, Mitsuko Asai, Seiichi Tanida
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Abstract
Maytansinol, maytanacine or maytansinol propionate is (are) produced by cultivating a microorganism belonging to the genus Nocardia and being capable of producing maytansinol, maytanacine or maytansinol propionate, causing the microorganism to accumulate maytansinol, maytanacine or maytansinol propionate and recovering the same. Those compounds are useful for anti-tumor agents.
Claims5
A method for preparing maytansinol, maytanacine or maytansinol propionate which comprises cultivating a microorganism belonging to the genus Nocardia and being capable of producing maytansinol, maytanacine or maytansinol propionate in a culture medium containing assimilable carbon sources and digestible nitrogen sources until maytansinol, maytanacine or maytansinol propionate is substantially accumulated therein, and recovering the same.
Dependencies are inferred from the claim text.