US 4,145,434 A · Tetracyclic derivatives and pharmaceutical compositions of matter

Abstract

The invention relates to novel dibenzo1,2;5,6! cyclophepta pyridine or -pyrrole derivatives, dibenzo2,3;6,7! oxepino pyridine or pyrrole derivatives, dibenzo2,3;6,7! thiepino pyridine or pyrrole derivatives and dibenzob,f! pyrido or pyrrole azepine derivatives of general formula: ##STR1## as well as the pharmaceutically acceptable salts and nitrogen oxides thereof, wherein R.sub.1, r.sub.2, r.sub.3 and R.sub.4 each represent hydrogen, hydroxy, halogen, an alkyl (1-6 C) group, an alkoxy or alkylthio group in which the alkyl group contains 1-6 C-atoms, or a trifluoromethyl group, R.sub.5 represents hydrogen, an alkyl group with 1-6 carbon atoms or an aralkyl group with 7-10 carbon atoms, M is the number 1 or 2, X represents oxygen, sulphur, the group ##STR2## or the group --CH.sub.2 -- and R.sub.6 represents hydrogen or a lower alkyl group (1-4 C), having CNS-depressant activity and excellent antihistamine and antiserotonin activities.

Claims35

Dependent claims

A compound of the formula

or a pharmaceutically acceptable non-toxic salt or nitrogen oxide thereof;
pg,33
wherein:
R.sub.1, r.sub.2, r.sub.3, and R.sub.4 represent a member selected from the group consisting of hydrogen, hydroxy, halogen, C.sub.1 - C.sub.6 alkyl, C.sub.1 - C.sub.6 alkoxy, C.sub.1 - C.sub.6 alkylthio, and trifluoromethyl;
R.sub.5 represents hydrogen, C.sub.1 - C.sub.6 alkyl or aralkyl having from 7 to 10 carbon atoms;
X represents oxygen;
and
m represents the number 1.

5 more elements

Dependencies are inferred from the claim text.

Tetracyclic derivatives and pharmaceutical compositions of matter

Life of this patent

Tetracyclic derivatives and pharmaceutical compositions of matter

Life of this patent

Abstract

Claims35