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US 4,145,410 AGranted
Method of preparing a controlled-release pharmaceutical preparation, and resulting composition
OwnerBarry D. Searsinventor
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Abstract
A method of preparing a controlled-release pharmaceutical compound for oral administration, which pharmaceutical compound is subject to enzymatic hydrolysis on oral administration, which method comprises encapsulating the pharmaceutical compound with a synthetic phosphatidyl compound having a modified polarhead moiety which increases the resistance of the phosphatidyl compound to phospholipase C hydrolysis.
Claims10
In a method for preparing a controlled-release pharmaceutical composition for oral administration, the method which comprises:
- forming an aqueous emulsion of phospholipid encapsulating agent with the pharmaceutical compound whose release is to be controlled;
- coagulating the emulsion to entrap the pharmaceutical compound within the phospholipid agent;
- and recovering the pharmaceutical composition as prepared, the improvement which comprises:
- employing as the phospholipid encapsulating agent a synthetic fatty-acid phosphatidyl C.sub.1 -C.sub.10 alkyl-N-C.sub.1 -C.sub.4 trialkyl quaternary-ammonium hydroxide compound, with the proviso that the alkyl of the alkyl-N group is not an ethyl group when the alkyl groups of the N-trialkyl radicals are methyl groups, and which phosphatidyl quaternary-ammonium compound is resistant to enzymatic hydrolysis of phospholipase C.
1 more element
Dependencies are inferred from the claim text.