7-Oxabicycloheptane- and 7-oxabicycloheptene compounds
AssigneeE. R. Squibb & Sons, Inc.
InventorPeter W. Sprague
Life of this patent
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Abstract
New 7-oxabicycloheptane- and 7-oxabicycloheptene compounds which have the general formula ##STR1## and intermediates therefor which have the general formulas ##STR2## are useful as cardiovascular agents.
Claims7
A compound of the formula ##STR23## wherein R.sup.1 is hydrogen or lower alkyl;
- R.sup.2 is --CHO, --CH.sub.2 OH or --CH.dbd.CH--R.sup.3 -- lower alkylene-CH.sub.3 ;
- R.sup.3 is keto or hydroxymethyl;
- and the dotted line is an optional double bond;
- said lower alkyl and lower alkylene groups having up to seven carbon atoms.
7-[3-(3-hydroxy-1-octenyl)-7-oxabicyclo[2.2.1]hept-2-yl]-5-heptenoic acid and C.sub.1 -C.sub.7 lower alkyl esters thereof.
[1R-(1.alpha.,2.beta.(5Z),3.beta.(1E,3S*),4.alpha.) ]-7-[3-(3-hydroxy-1-octenyl)-7-oxabicyclo[2.2.1]hept-2-yl]-5-heptenoic acid.
[1R-(1.alpha.,2.beta.(5Z),3.beta.(1E,3R*),4.alpha.)]-7-[3-(3-hydroxy-1-o ctenyl)-7-oxabicyclo[2.2.1]hept-2-yl]-5-heptenoic acid.
Dependencies are inferred from the claim text.